IDENTIFYING SMALL MOLECULES FOR PROTECTING CHONDROCYTE FUNCTION AND MATRIX INTEGRITY AFTER CONTROLLED COMPRESSIVE INJURY

Identifying small molecules for protecting chondrocyte function and matrix integrity after controlled compressive injury

Objective: Articular cartilage injury is central for the development of post-traumatic osteoarthritis (PTOA).With few disease-modifying therapies successful at offsetting progressive osteoarthritis (OA), our goal is to use a high throughput screening platform of cartilage injury to identify novel chondroprotective compounds.Targeting articular cart

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Markers and antibodies for characterization of goat mammary tissue and the derived primary epithelial cell cultures

ABSTRACT A selection of commercially available antibodies, targeted against markers employed in studies of mammary gland biology, was tested to determine their reactivity in goat mammary tissue and the derived tissue cultures.Expression of the markers smooth muscle actin ( SMA ), selected keratins ( KRT ) 5, 14, 18 , and 19 , CD24 molecule ( CD24 )

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